Affliction Locks, 5.0.4
While Demo and Destro got brand new secondaray resources, Affliction still uses Soul Shards as their spec mechanic. They function pretty much the same way - Soulburn to unlock a bonus mechanic on some spells, with Haunt costing one just to cast, but now being a nuke with no cooldown. The main change is the way we get them, and the list of spells you can burn one on, not to mention they float above your head now and look awesome.
Demon Summons - Instant cast, same as always
Drain / Harvest Life - +50 / 33% healing rather than double speed
Health Funnel - Instant transfer, but doesn't work when upgraded to Soul Link
Curses - Sort of like Jinx, but it directly applies it to every target hit, no more primary curse target.
Seed of Corruption - AOE Corruption, same as always
Unending Breath - Waterwalking
Soul Swap - The big one - it drops all three DoTs on a target instantly.
Some spells have been changed entirely. Dark Intent, Curse of Agony, Haunt, Shadow Bolt, and Drain Soul are what affect us primarily. DI was switched to a +10% spell power boost for the entire raid, no more dot critting mechanic. Curse of Agony is now just Agony, and while it does ramp up its damage over time still, the way it does so is completely different - rather than a linear progression, every time it deals damage the target gets a stack of Agony, up to 10, and it does damage based on those. Haunt isn't a DoT anymore, and it burns a soul shard just to cast, but it has no cooldown and still boosts DoT damage while being a decently hard hitting nuke. Shadow Bolt morphs into Malefic Grasp for Affliction, which is a channelled spell that forces all of your other dots to tick for half normal damage whenever it does. Drain Soul ticks much faster now, for a fair bit less damage, and gives you a Soul Shard every two ticks. While the target is under 20%, it still executes for double damage now, but also forces your other dots to tick for full damage every time it does.
The basic rotation now, with that in mind, is to keep your dots up, Haunt when you have two or more shards and the effect is about to end, and otherwise Channel Malefic Grasp to 20%, and Drain Soul after that. In an AOE situation, Soul Burn for Seed of Corruption and Curse of the Elements, while dropping SoC afterwards just like normal.
Optimal talents are Harvest Life, Mortal Coil, Soul Link, Burning Rush, and Grimoire of Sacrifice. With these, Drain Life morphs into a stronger targetted AOE, that drains off everything near your channel target. Mortal Coil is basically a remake of Death Coil, instant cast fear with a 15% max health return now. Soul Link has changed to be a full 50% shared healing and damage link with your demon, but it cuts the pet's max health by half. Burning Rush is a toggle that drains 4% max HP a second for 50% bonus move speed. Grimoire of Sacrifice is where the real change enters into effect - it kills your demon, boosting Malefic Grasp, Haunt, and Drain Soul's damage by a lovely 50%, giving you passive health regen, and morphing your Command Demon skill into a self-supplied spell depending on what demon you killed. On top of that, it alters the function of Soul Link - if you have the talent, Sacrifice gives you a flat 20% health bonus on top of everything else.
Imp - Singe Magic
Void Walker - Shadow Bulwark
Succubus - Seduction
Fel Hunter - Spell Lock
Fel Guard - Pursuit
This makes it a choice on your part as to what utility you want to have. Being Affliction we can't actually get the Fel Guard ability, but the others are free. Singe is a friendly magic Dispel, while Bulwark is a Last Stand copy. Seduction is the same as always, but seems as though it's no longer channelled, letting you CC something without losing your casting ability. Spell Lock is an interrupt. Personally I've been going with the fel hunter sacrifice because having an interrupt is very nice, but in a fight you could always Soul Burn summon and sacrifice another demon to switch.
Glyphs are fairly simple for Affliction. Soul Shards and Dark Soul are the main ones, with an open slot for whatever else you want. I'd active encourage the Soul Well minor one though, because it puts a very large and visible light pattern on the ground around the well, making it very easy to see.